6533b7d2fe1ef96bd125e0d0

RESEARCH PRODUCT

Crystal structure of [Cu(N-quinolin-8-yl-p-toluenesulfonamidate)2]: study of its interaction with DNA and hydrogen peroxide

Joaquín BorrásAlfonso CastiñeirasBenigno MacíasIsabel Garcı́aEmilio FizMaría V. VillaMarta González-álvarez

subject

StereochemistryCrystal structureTriclinic crystal systemCrystallography X-RayBiochemistryIonInorganic Chemistrychemistry.chemical_compoundCleaveOrganometallic CompoundsHydrogen peroxidechemistry.chemical_classificationSulfonamidesCopper complexDose-Response Relationship DrugMolecular StructureHydrolysisSpectrum AnalysisDNAHydrogen PeroxideSulfonamideCrystallographychemistryQuinolinesCopperDNADNA DamagePlasmids

description

A new copper complex with N-quinolin-8-yl-p-toulenesulfonamide has been prepared and characterised. The compound crystallises in the triclinic system, space group P1, with a=13.457(3), b=15.067(5), c=18.589(3) A; α=112.05(2), β=93.92(2), γ=108.30(2)° and Z=4. The geometry of the Cu(II) ion is distorted square planar. The N-quinolin-8-yl-p-toulenesulfonamidate anion behaves as a bidentate ligand through the N s u l f o n a m i d a t e and N q u i n o l i n e atoms. The complex does not cleave DNA in the presence of hydrogen peroxide.

yearjournalcountryeditionlanguage
2001-12-26Journal of Inorganic Biochemistry
https://doi.org/10.1016/s0162-0134(01)00302-6