6533b7d2fe1ef96bd125e1e0
RESEARCH PRODUCT
Indications of the occurrence of inflammatory reactions in the clinical improvement phase in multiple sclerosis patients.
Rolf RöderH. C. HopfHenriette GiesK.p. Hammannsubject
AdultCentral Nervous SystemMaleMultiple SclerosisDiseasePeripheral blood mononuclear cellMonocytesAdrenocorticotropic HormonePrednisoneMedicineHumansIn patientInflammationBiological Productsbusiness.industryMultiple sclerosisClinical courseGeneral Medicinemedicine.diseasePeripheralNeurologyImmunologyLuminescent MeasurementsCytokinesPrednisoneFemaleNeurology (clinical)businessmedicine.drugdescription
– In patients with multiple sclerosis (MS) the spontaneous burst activity (BA) of peripheral blood mononuclear cells was related to the clinical course of the disease. In five patients clinical improvement was found while the BA was significantly increased (more than 300% of the controls). During the appearance of new or deteriorating signs and in the period without clinical changes, the BA was not at all or not markedly increased. In two patients without clinical improvement the BA did not reach levels above 300% of the controls. Our findings suggest that inflammatory reactions represented by the BA occur in the phase of clinical improvement. Since burst-stimulating activity was found in the serum of MS patients, cytokines produced by activated immuno-competent cells are assumed to cause the increased BA. A possible role of prednisone and ACTH on the BA of peripheral mononuclear leucocytes is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-01-29 | Acta neurologica Scandinavica |