6533b7d2fe1ef96bd125ea80
RESEARCH PRODUCT
Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis
Thobias M. KalengaJackson T. MollelJoanna SaidAndreas OrthaberJas S. WardYoseph AtilawDaniel UmerewenezaMonica M. NdoileJoan J. E. MunissiKari RissanenEdward TrybalaTomas BergströmStephen S. NyandoroMate Erdelyisubject
PharmacologyOrganisk kemibioaktiiviset yhdisteetOrganic ChemistryPharmaceutical SciencemyrkyllisyysluonnonaineetAnalytical ChemistryterpeenitComplementary and alternative medicinetyräkkikasvitDrug DiscoveryMolecular Medicineinhibiittoritdescription
The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and β-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC50 11.5 μg/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC50 52 μg/mL. The isolated compounds 1–3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at ≥100 μM. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2022-09-08 |