6533b7d2fe1ef96bd125f4fd
RESEARCH PRODUCT
Effect of the basidiomycete Poria cocos on experimental dermatitis and other inflammatory conditions.
José Luis RíosSalvador MáñezMaría Del Carmen RecioM. J. CuéllarMaria Jose JustRosa M. Ginersubject
Administration TopicalAnti-Inflammatory AgentsAdministration OralDermatitisPharmacognosyPharmacologyCarrageenanOxazolonechemistry.chemical_compoundMiceEdemaDrug DiscoverymedicineAnimalsInflammationArachidonic Acidintegumentary systemPlant ExtractsBasidiomycotaGeneral ChemistryGeneral MedicineTriterpenesCarrageenanchemistryDelayed hypersensitivityTetradecanoylphorbol AcetateImmunologyPhorbolTetradecanoylphorbol AcetateArachidonic acidFemalemedicine.symptomdescription
The hydroalcoholic extract from P. cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID50 on acute TPA edema was 4.7 x 10(-3) and 6.8 x 10(-4) mumol/ear, respectively.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-03-01 | Chemicalpharmaceutical bulletin |