6533b7d3fe1ef96bd125fdff
RESEARCH PRODUCT
Enantioselective copper-aminopyridine-catalyzed aza-Henry reaction with chelating N-(2-pyridyl)sulfonyl imines
Gonzalo BlayAna EscamillaJosé R. PedroAmparo Sanz-marcoVictor Hernandez‐olmossubject
Pharmacologychemistry.chemical_classificationSulfonylAldimineNitroaldol reactionNucleophilic additionOrganic ChemistryEnantioselective synthesisMedicinal chemistryCatalysisAnalytical ChemistrySulfonamidechemistryDrug DiscoveryOrganic chemistryChirality (chemistry)SpectroscopyAminopyridinesdescription
This article describes a copper-catalyzed aza-Henry reaction. Copper complexes of camphor-derived aminopyridines catalyze the addition of nitromethane to N-(2-pyridyl)sulfonyl aldimines to give the corresponding β-nitrosulfonamides with good yields and variable enantiomeric excesses (up to 83%). An example of transformation of these compounds into N-(2-pyridyl)sulfonyl-α-amino acids and deprotection of the sulfonamide with Mg–MeOH is provided. Chirality 24:441–450, 2012. © 2012 Wiley Periodicals, Inc.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-04-28 | Chirality |