6533b7d3fe1ef96bd1260103

RESEARCH PRODUCT

Sorting of Enhanced Reference Raman Spectra of a Single Amino Acid Molecule

Laurent MarkeyAlain DereuxThibault BruléEric FinotAymeric LerayHélène Yockell-lelièvreAlexandre BouhelierJérémie Margueritat

subject

chemistry.chemical_classification[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics]Quantitative Biology::BiomoleculesSortingNanoparticleActive surfaceQuantitative Biology::GenomicsSpectral lineSurfaces Coatings and FilmsElectronic Optical and Magnetic MaterialsAmino acidCrystallographysymbols.namesakeGeneral EnergyAdsorptionchemistrysymbolsMoleculePhysical and Theoretical ChemistryRaman spectroscopyComputingMilieux_MISCELLANEOUS

description

In this contribution, we report the identification of the principal reference Raman spectra of a single cystein molecule. To that purpose, we design an active Surface Enhanced Raman Spectroscopy (SERS) template based on surfactant-less Chebyshev nanoparticles operating in a microfluidic platform. A principal component analysis is obtained from fluctuating spectra to sort the reference spectra of cystein. The assignment of Raman bands brings new insight into the conformation of an amino acid adsorbed onto gold nanoparticle.

https://doi.org/10.1021/jp504395c