6533b7d3fe1ef96bd126022d
RESEARCH PRODUCT
Detection of lung cancer bio-markers in human breath using a micro-fabricated air analyzer
Guy WeberGeoffrey GregisJean-baptiste SanchezIgor BezverkhyyVanessa FierroJean-pierre BellatFranck BergerAlain CelzardSébastien Schaefersubject
Spectrum analyzerMedical diagnosticMaterials scienceSilicon[ SPI.MAT ] Engineering Sciences [physics]/MaterialsOxide[ PHYS.COND.CM-MS ] Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci]chemistry.chemical_element[SPI.MAT]Engineering Sciences [physics]/Materialschemistry.chemical_compoundAdsorption[SPI.MECA.MEMA]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph]medicineGas detector[SPI.ACOU]Engineering Sciences [physics]/Acoustics [physics.class-ph]Chromatography[ SPI.ACOU ] Engineering Sciences [physics]/Acoustics [physics.class-ph][CHIM.MATE]Chemical Sciences/Material chemistry[ SPI.MECA.THER ] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Thermics [physics.class-ph]Toluene[ CHIM.POLY ] Chemical Sciences/Polymers[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism[CHIM.POLY]Chemical Sciences/Polymerschemistry[ CHIM.MATE ] Chemical Sciences/Material chemistry[ SPI.MECA.MEMA ] Engineering Sciences [physics]/Mechanics [physics.med-ph]/Mechanics of materials [physics.class-ph][ SPI.ELEC ] Engineering Sciences [physics]/Electromagnetism[PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci][SPI.MECA.THER]Engineering Sciences [physics]/Mechanics [physics.med-ph]/Thermics [physics.class-ph]Activated carbonmedicine.drugdescription
International audience; The analysis of volatile organic compounds (VOCs) that are linked to lung cancer is a very promising way in medical diagnostics because it is non-invasive and potentially inexpensive. In that sense, a silicon micro-analytical platform consisting of a three-dimensional micro-preconcentrator coupled to a silicon spiral gas chromatographic micro-column was built. A metal oxide-based gas sensor acted as a miniaturized gas detector. This system allowed selective detection of VOCs at the sub-ppm level. The present study is focused first on the chromatographic air analyzer fabrication and second on the selection of an appropriate adsorbent. Various adsorbents such as activated carbon microspheres and zeolites were then studied in order to identify the best material for the concentration of one representative lung cancer biomarker: toluene.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-01-01 |