6533b7d3fe1ef96bd1260275

RESEARCH PRODUCT

Extensive migration of young neurons into the infant human frontal lobe

José Manuel García-verdugoDavid JamesArturo Alvarez-buyllaMercedes F. ParedesEric J. HuangHosung KimDavid H. RowitchDavid H. RowitchJennifer A. CotterCarissa NgPatrick S. McquillenDuan XuKadellyn SandovalSara Gil-perotinSara Gil-perotin

subject

Doublecortin Domain Proteins0301 basic medicineNeurogenesisNeuropeptideBiologyInhibitory postsynaptic potentialGyrus Cinguli03 medical and health sciencesLateral ventricles0302 clinical medicineCell MovementInterneuronsLateral VentriclesCorrespondenceNeuroplasticitymedicineHumansGyrus cinguliAnterior cingulate cortexNeuronsNeuronal PlasticityMultidisciplinaryNeuropeptidesNeurogenesisInfantAnatomyFrontal Lobe030104 developmental biologymedicine.anatomical_structureFrontal lobeMicrotubule-Associated Proteins030217 neurology & neurosurgery

description

Building the human brain As the brain develops, neurons migrate from zones of proliferation to their final locations, where they begin to build circuits. Paredes et al. have discovered that shortly after birth, a group of neurons that proliferates near the ventricles migrates in chains alongside circulatory vessels into the frontal lobes (see the Perspective by McKenzie and Fishell). Young neurons that migrate postnatally into the anterior cingulate cortex then develop features of inhibitory interneurons. The number of migratory cells decreases over the first 7 months of life, and by 2 years of age, migratory cells are not evident. Any damage during migration, such as hypoxia, may affect the child's subsequent physical and behavioral development. Science , this issue p. 81 ; see also p. 38

yearjournalcountryeditionlanguage
2016-10-07Science
https://doi.org/10.1126/science.aaf7073