6533b7d3fe1ef96bd12609a2
RESEARCH PRODUCT
Polymorphisms cyclooxygenase-2 -765G>C and interleukin-6 -174G>C are associated with serum inflammation markers in a high cardiovascular risk population and do not modify the response to a Mediterranean diet supplemented with virgin olive oil or nuts
Valentina Ruiz-gutiérrezEnrique Gómez-graciaManuel Conde HerreraMaría Isabel CovasJavier Díez-espinoRamon EstruchRamon EstruchMiquel FiolErnest VinyolesJosé I. GonzálezJosé I. GonzálezDolores CorellaDolores CorellaCarlos LahozRosa LamuelaEmilio RosGuillermo-t. SáezOlga PortolésPaula CarrascoFernando ArósMònica BullóJosé Manuel Santossubject
MaleMediterranean dietVascular cell adhesion molecule-1Suplements nutritiusMedicine (miscellaneous)InterleucinesDiet MediterraneanOlis vegetalsPolymorphism (computer science)Nutseducation.field_of_studyNutrition and DieteticsbiologyBiochemical markersPlant oilsMiddle AgedIntercellular Adhesion Molecule-1Dietary supplementsInflamacióOli d'olivaC-Reactive ProteinCardiovascular diseasesCardiovascular DiseasesMarcadors bioquímicsFemalemedicine.symptommedicine.medical_specialtyDiet therapyPopulationVascular Cell Adhesion Molecule-1InflammationDried fruitGenetic polymorphismsMediterranean cookingInternal medicineCuina mediterràniamedicineHumansPlant OilsGenetic variabilityInterleukin 6educationOlive OilAgedInflammationPolymorphism GeneticInterleukin-6Malalties cardiovascularsPolimorfisme genèticInterleukinsEndocrinologyGene Expression RegulationCyclooxygenase 2Immunologybiology.proteinCyclooxygenaseVegetable oilsFruita secaBiomarkersOlive oildescription
Inflammation is involved in cardiovascular diseases. Some studies have found that the Mediterranean diet (MD) can reduce serum concentrations of inflammation markers. However, none of these studies have analyzed the influence of genetic variability in such a response. Our objective was to study the effect of the -765G>C polymorphism in the cyclooxygenase-2 (COX-2) gene and the -174G>C polymorphism in the interleukin-6 (IL-6) gene on serum concentrations of IL-6, C-reactive protein, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule-1 as well as their influence on the response to a nutritional intervention with MD. An intervention study in a high cardiovascular risk Mediterranean population (314 men and 407 women) was undertaken. Participants were randomly assigned to consume a low-fat control diet or a MD supplemented with virgin olive oil or nuts. Measures were obtained at baseline and after a 3-mo intervention period. At baseline, the COX-2 -765G>C polymorphism was associated with lower serum IL-6 (5.85 ± 4.82 in GG vs. 4.74 ± 4.14 ng/L in C-allele carriers; P = 0.002) and ICAM-1 (265.8 ± 114.8 in GG vs. 243.0 ± 107.1 μg/L in C-carriers; P = 0.018) concentrations. These differences remained significant after multivariate adjustment. The IL-6 -174G>C polymorphism was associated with higher (CC vs. G-carriers) serum ICAM-1 concentrations in both men and women and with higher serum IL-6 concentrations in men. Following the dietary intervention, no significant gene x diet interactions were found. In conclusion, although COX-2 -765G>C and IL-6 -174G>C polymorphisms were associated with inflammation, consuming a MD (either supplemented with virgin olive oil or nuts) reduced the concentration of inflammation markers regardless of these polymorphisms.
year | journal | country | edition | language |
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2009-01-01 |