Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

6533b7d3fe1ef96bd1260a07

RESEARCH PRODUCT

Synthesis and pharmacological evaluation of several ring-contracted amantadine analogs

Pelayo Camps Santiago Vázquez Vanessa Romero Mercè Pallàs Marta López-querol María D. Duque S. Radhika Prathalingam Lieve Naesens Diego Cortes John M. Kelly Dolores Ivorra Francesc X. Sureda Antoni Camins Erik De Clercq

subject

Rimantadine Stereochemistry Dopamine education Clinical Biochemistry Pharmaceutical Science macromolecular substances Pharmacology medicine.disease_cause Antiviral Agents Receptors N-Methyl-D-Aspartate Biochemistry Chemical synthesis Article Inhibitory Concentration 50 Dogs Polycyclic compound Memantine Trypanosomiasis Dopamine Drug Discovery Amantadine medicine Influenza A virus Animals NMDA receptor antagonist Molecular Biology Cells Cultured chemistry.chemical_classification Chemistry Organic Chemistry Amantadine Polycyclic cage compounds Biological activity Influenza nervous system Influenza A virus Molecular Medicine NMDA receptor medicine.drug

description

Graphical abstract Several bisnoradamantylamines and noradamantylamines have been synthesized and their antiviral, trypanocidal, NMDA receptor antagonist, and dopamine reuptake inhibitory activities have been studied.

year	journal	country	edition	language
2008-12-01	Bioorganic & Medicinal Chemistry

https://doi.org/10.1016/j.bmc.2008.10.028

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