6533b7d3fe1ef96bd1260b39

RESEARCH PRODUCT

Binding properties of mono-(6-deoxy-6-amino)-β-cyclodextrin towards p-nitroaniline derivatives: a polarimetric study

Renato NotoSerena RielaPaolo Lo MeoFrancesca D'annaMichelangelo Gruttadauria

subject

chemistry.chemical_classificationCyclodextrinStereochemistryOrganic ChemistrySupramolecular chemistrySolvationNitro compoundcyclodextrins polarimetric study host-guest complexes stability constantsSettore CHIM/06 - Chimica OrganicaBiochemistryInclusion compoundSolventchemistry.chemical_compoundchemistryDrug DiscoveryMoleculeAmine gas treating

description

Abstract Polarimetry was used in order to investigate the formation of supramolecular complexes between mono-6-amino-β-cyclodextrin and various p-nitroaniline derivatives at two different pH values. Comparison with the behaviour of native β-cyclodextrin gave us the opportunity to consider the effect exerted by the presence of charged groups, having different solvation requirements, on the binding equilibrium. Data offer some support to the hypothesis of ‘dynamic co-inclusion’ of solvent molecules within the host–guest complex.

yearjournalcountryeditionlanguage
2009-12-01Tetrahedron
https://doi.org/10.1016/j.tet.2009.10.032