6533b7d3fe1ef96bd1260c66

RESEARCH PRODUCT

Cross-linked natural IntegroPectin films from citrus biowaste with intrinsic antimicrobial activity

Elena PiacenzaAlessandro PresentatoRosa AlduinaAntonino ScurriaMario PagliaroLorenzo AlbaneseFrancesco MeneguzzoRosaria CiriminnaDelia Chillura Martino

subject

Polymers and PlasticsAntimicrobial filmsTerpenesControlled releasePolyphenolsSettore BIO/19 - Microbiologia GeneraleCitrus pectinPectin filmsSettore CHIM/02 - Chimica Fisica

description

AbstractPectin recovered via hydrodynamic cavitation (IntegroPectin) from lemon and grapefruit agri-food waste intrinsically containing antimicrobial bioactive substances (flavonoids, phenolic acids, terpenes, and terpenoids) was used to generate innovative and eco-compatible films that efficiently inhibit the growth of Gram-negative pathogens. Extensive characterization of films confirmed the presence of these substances, which differently interact with the polysaccharide polymer (pectin), plasticizer (glycerol), surfactant (Tween 60), and cross-linker (Ca2+), conferring to these films a unique structure. Besides, IntegroPectin-based films constitute versatile systems for the sustained, controlled, and slow-release (up to 72 h) of bioactive substances in an aqueous environment. This feature is crucial for the good in vitro antimicrobial activity exerted by IntegroPectin films against three Gram-negative bacteria (two indicator pathogen strains Pseudomonas aeruginosa ATCC 10145, P. aeruginosa PAO1, and the clinical isolate Klebsiella pneumoniae) that are involved in the global emergence of the antimicrobial resistance. Graphical abstract

yearjournalcountryeditionlanguage
2022-01-28
10.1007/s10570-022-04627-1https://hdl.handle.net/10447/584172