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RESEARCH PRODUCT
Catalytic Enantioselective Friedel–Crafts Reactions of Naphthols and Electron-Rich Phenols
Carlos VilaMarc Montesinos-magranerJosé R. PedroGonzalo Blaysubject
Nucleophilic addition010405 organic chemistryOrganic ChemistryEnantioselective synthesis010402 general chemistry01 natural sciencesCatalysis0104 chemical sciencesStereocenterCatalysischemistry.chemical_compoundchemistryElectrophileOrganic chemistryPhenolsFriedel–Crafts reactionConjugatedescription
The enantioselective Friedel–Crafts reaction is a powerful tool for the construction of benzylic stereocenters in a stereodefined manner. Significant advances have already been achieved with heteroarenes such as indoles and pyrroles; however, the reaction with homoarenes is less developed. This short review covers the most relevant literature on enantioselective Friedel–Crafts reactions with naphthols and phenols. 1 Introduction 2 Friedel–Crafts Reactions Involving 1,2-Nucleophilic Addition to C=X Bonds 3 Friedel–Crafts Reactions Involving Conjugate Nucleophilic Addition to Electrophilic C=C Bonds 4 Friedel–Crafts Reactions Involving π-Allylic Complexes as Electrophiles 5 ipso-Friedel–Crafts Reactions 6 Conclusions
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-04-20 | Synthesis |