6533b7d3fe1ef96bd1261393
RESEARCH PRODUCT
Evidence for characteristic vascular patterns in solid tumours: quantitative studies using corrosion casts
C Van AckernMarco PrestaE. FaitWolf MalkuschSally A. HillC. S. ParkinsDavid J. ChaplinM. A. KonerdingJuliana DenekampB Klapthorsubject
Cancer ResearchPathologymedicine.medical_specialtyAngiogenesisTransplantation Heterologousvascular patternNormal tissueMice NudeAdenocarcinomaBiologyCorrosion CastingVascular architectureMiceMicroscopyTumor Cells CulturedmedicineAnimalsHumansmicrovascular corrosion castingtumourCarcinomaRegular ArticleNeoplasms ExperimentalAnatomymedicine.diseaseEndometrial NeoplasmsTransplantationxenograftsOncologyVascular networkrodentsMice Inbred CBAMicroscopy Electron ScanningFemaleSarcoma ExperimentalSarcomaCorrosion CastingNeoplasm Transplantationdescription
The vascular architecture of four different tumour cell lines (CaX, CaNT, SaS, HEC-1B) transplanted subcutaneously in mice was examined by means of microvascular corrosion casting in order to determine whether there is a characteristic vascular pattern for different tumour types and whether it differs significantly from two normal tissues, muscle and gut. Three-dimensional reconstructed scanning electron microscope images were used for quantitative measurements. Vessel diameters, intervessel and interbranch distances showed large differences between tumour types, whereas the branching angles were similar. In all tumours, the variability of the vessel diameters was significantly higher than in normal tissue. The quantitative data provide strong evidence for a characteristic vascular network determined by the tumour cells themselves. © 1999 Cancer Research Campaign
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-06-09 | British Journal of Cancer |