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RESEARCH PRODUCT

Influence of Lymphangio (L), Vascular (V), and Perineural (Pn) Invasion on Recurrence and Survival of Resected Intrahepatic Cholangiocarcinoma

Hauke LangJ. BaumgartMaria Hoppe-lotichiusFabian BartschJens MittlerBeate K. StraubRabea MargiesFriedrich FoersterLisa-katharina HeuftStefan HeinrichTiemo S. GerberArndt Weinmann

subject

medicine.medical_specialtyPerineural invasionMalignancyGastroenterologysurvivalArticleResectionVascular invasion03 medical and health sciences0302 clinical medicineintrahepatic cholangiocarcinomaInternal medicineStatistical analysesmedicineOverall survivalvascular invasionliver surgeryIntrahepatic Cholangiocarcinomabusiness.industryRlymphangioinvasionGeneral Medicineperineural invasionmedicine.diseaseTumor recurrence030220 oncology & carcinogenesisMedicine030211 gastroenterology & hepatologybusiness

description

(1) Background: Intrahepatic cholangiocarcinoma (ICC) is a rare malignancy. Besides tumor, nodal, and metastatic status, the UICC TNM classification describes further parameters such as lymphangio- (L0/L1), vascular (V0/V1/V2), and perineural invasion (Pn0/Pn1). The aim of this study was to analyze the influence of these parameters on recurrence and survival. (2) Methods: All surgical explorations for patients with ICC between January 2008 and June 2018 were collected and further analyzed in our institutional database. Statistical analyses focused on perineural, lymphangio-, and vascular invasion examined histologically and their influence on tumor recurrence and survival. (3) Results: Of 210 patients who underwent surgical exploration, 150 underwent curative-intended resection. Perineural invasion was present in 41, lymphangioinvasion in 21, and vascular invasion in 37 patients (V1 n = 34, V2 n = 3). Presence of P1, V+ and L1 was significantly associated with positivity of each other of these factors (p &lt

yearjournalcountryeditionlanguage
2021-05-30Journal of Clinical Medicine
10.3390/jcm10112426http://dx.doi.org/10.3390/jcm10112426