6533b7d3fe1ef96bd126153a
RESEARCH PRODUCT
Intravenous high-dose furosemide and hypertonic saline solutions for refractory heart failure and ascites.
Antonino TuttolomondoAntonio PintoGiuseppe LicataGaspare Parrinellosubject
Liver CirrhosisCirrhosisFurosemideAscitesmedicineParacentesisHumansAdverse effectDiureticsInfusions IntravenousHepatic encephalopathyHeart FailureSaline Solution Hypertonicmedicine.diagnostic_testCardio-Renal Syndromebusiness.industryFurosemideAscitesmedicine.diseaseHypertonic salineNephrologyAnesthesiaHeart failuremedicine.symptombusinessmedicine.drugdescription
Several studies have shown the efficacy of hypertonic saline solution infusion in conditions in which regional organ blood flow is impaired. Our group has shown that treatment of patients with diuretic-resistant heart failure with high-dose furosemide plus hypertonic saline is effective and well tolerated, improving symptoms of congestion, reducing plasma levels of markers of neurohormonal and inflammatory activation, decreasing hospital readmission rates, and reducing long-term mortality. The same regimen was shown to be better than repeated paracentesis in patients with cirrhosis and refractory ascites, yielding better control of ascites, pleural effusions, and/or leg edema without an increase of common adverse effects linked to high-dose furosemide such as hepatic encephalopathy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-11-01 | Seminars in nephrology |