6533b7d4fe1ef96bd1261e0d

RESEARCH PRODUCT

Thymidine-dependent Staphylococcus aureus small-colony variants: human pathogens that are relevant not only in cases of cystic fibrosis lung disease.

Stephan H. SaumSilke BesierVolker BradeThomas A. WichelhausAnnabelle EhrhartJohannes ZanderEkkehard SiegelKlaus-peter Hunfeld

subject

Microbiology (medical)AdultMaleStaphylococcus aureusPancreatic diseaseCystic FibrosisPeritonitisPeritonitismedicine.disease_causeCystic fibrosischemistry.chemical_compoundSepsisPulmonary fibrosismedicineHumansBronchitisChildbusiness.industryRespiratory diseaseBacteriologyPneumoniaMiddle AgedStaphylococcal Infectionsmedicine.diseasechemistryStaphylococcus aureusImmunologyBronchitisFemalebusinessThymidineThymidine

description

ABSTRACT We report the isolation of thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus from unusual infection sites of patients with chronic soft tissue infection, tympanitis, bronchitis, peritonitis, and septicemia. Furthermore, we provide evidence that the essential growth factor for TD-SCVs, i.e., thymidine, and its metabolite dTMP are present in various human specimens.

yearjournalcountryeditionlanguage
2008-11-01Journal of clinical microbiology
10.1128/jcm.01440-08https://pubmed.ncbi.nlm.nih.gov/18832128