0000000000040714

AUTHOR

Ekkehard Siegel

showing 7 related works from this author

Eosinophilic Meningitis due toAngiostrongylus cantonensisin Germany

2009

We report a case of eosinophilic meningitis due to Angiostrongylus cantonensis in a patient who returned from Thailand. The presence of a compatible epidemiologic history and eosinophilia in cerebrospinal fluid (CSF) lead to the diagnosis, which was confirmed by detection of specific antibodies. After treatment with albendazole and corticosteroids he recovered completely.

AdultMalePathologymedicine.medical_specialtyEosinophilic MeningitisBlotting WesternAlbendazoleAlbendazoleCerebrospinal fluidAdrenal Cortex HormonesGermanyEosinophiliamedicineAnimalsHumansEosinophiliaHelminthsMeningitisCerebrospinal FluidStrongylida InfectionsAnthelminticsTravelbiologybusiness.industryAngiostrongylus cantonensisGeneral MedicineThailandbiology.organism_classificationmedicine.diseaseAngiostrongylus cantonensisSpecific antibodyImmunologymedicine.symptombusinessMeningitismedicine.drugJournal of Travel Medicine
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Improvement of a Clinical Score for Necrotizing Fasciitis: 'Pain Out of Proportion' and High CRP Levels Aid the Diagnosis.

2015

Necrotizing fasciitis (NF) is a rare mono-/polymicrobial skin infection that spreads to underlying tissues. NF is quickly progressing and leads to life threatening situations. Immediate surgical debridement together with i.v. antibiotic administration is required to avoid fatal outcome. Early diagnosis is often delayed due to underestimation or confusion with cellulitis. We now compared the initial clinical and laboratory presentation of NF and cellulitis in detail to assess if a typical pattern can be identified that aids timely diagnosis of NF and avoidance of fatal outcome. 138 different clinical and laboratory features of 29 NF patients were compared to those of 59 age- and gender match…

AdultMalemedicine.medical_specialtyPainlcsh:MedicineSeverity of Illness IndexErysipelasDiagnosis DifferentialYoung AdultSex FactorsInternal medicineSeverity of illnessmedicineHumansFasciitis NecrotizingFasciitislcsh:ScienceAgedPain MeasurementRetrospective StudiesAged 80 and overMultidisciplinarybiologybusiness.industrySoft Tissue InfectionsC-reactive proteinlcsh:RCase-control studyCellulitisRetrospective cohort studyMiddle Agedmedicine.diseaseSurgeryC-Reactive ProteinTreatment OutcomeDebridementCase-Control StudiesCellulitisbiology.proteinFemalelcsh:QDifferential diagnosisbusinessResearch ArticlePLoS ONE
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Thymidine-dependent Staphylococcus aureus small-colony variants: human pathogens that are relevant not only in cases of cystic fibrosis lung disease.

2008

ABSTRACT We report the isolation of thymidine-dependent small-colony variants (TD-SCVs) of Staphylococcus aureus from unusual infection sites of patients with chronic soft tissue infection, tympanitis, bronchitis, peritonitis, and septicemia. Furthermore, we provide evidence that the essential growth factor for TD-SCVs, i.e., thymidine, and its metabolite dTMP are present in various human specimens.

Microbiology (medical)AdultMaleStaphylococcus aureusPancreatic diseaseCystic FibrosisPeritonitisPeritonitismedicine.disease_causeCystic fibrosischemistry.chemical_compoundSepsisPulmonary fibrosismedicineHumansBronchitisChildbusiness.industryRespiratory diseaseBacteriologyPneumoniaMiddle AgedStaphylococcal Infectionsmedicine.diseasechemistryStaphylococcus aureusImmunologyBronchitisFemalebusinessThymidineThymidineJournal of clinical microbiology
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Lethal systemic and brain infection caused by Prototheca zopfii algae in a patient with acute myeloid leukemia

2021

Systemic protothecosis is an exceptionally rare cause of sepsis with few available therapeutic options. Here, we report on a female patient with newly diagnosed acute myeloid leukemia who died after start of chemotherapy due to a severe septic shock caused by a disseminated systemic infection with Prototheca zopfii including encephalitis.

0301 basic medicineProtothecosisMedicine (General)QH301-705.5medicine.medical_treatmentProtothecosis030106 microbiology030231 tropical medicinePrototheca zopfiiCase ReportMicrobiologySepsis03 medical and health sciences0302 clinical medicineR5-920medicineImmunodeficiencyBiology (General)ImmunodeficiencyChemotherapyLeukemiabusiness.industrySeptic shockMyeloid leukemiamedicine.diseaseLeukemiaInfectious DiseasesImmunologyEncephalitisbusinessEncephalitisMedical Mycology Case Reports
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Diagnosing Helicobacter pylori in vivo by confocal laser endoscopy.

2005

Background & Aims: Confocal laser endomicroscopy enables subsurface microscopic imaging of living tissue during ongoing endoscopy. This case report describes the in vivo detection of Helicobacter pylori by endomicroscopy.Methods: Endomicroscopy (Pentax, Tokyo, EC-3870CIFK) was performed by using two different contrast stains: Topical Acriflavine in addition to intravenously applied fluorescein netted the surface and allowed identification of focal accumulation of Helicobacter pylori at the surface and in deeper layer of the gastric epithelium. Biopsies were performed at the antrum and corpus for urease testing and histology. In addition, biopsies were cultured for Helicobacter pylori. Cultu…

Malemedicine.medical_specialtyPathologyConfocalAdministration TopicalContrast MediaGastroenterologySensitivity and SpecificityEndoscopy Gastrointestinallaw.inventionHelicobacter InfectionsDiagnosis Differentialchemistry.chemical_compoundIn vivoConfocal microscopylawInternal medicinemedicineEndomicroscopyHumansAcriflavineAgedFluorescent DyesMicroscopy ConfocalHepatologybiologyHelicobacter pyloriGastroenterologyHistologyHelicobacter pyloribiology.organism_classificationchemistryAcriflavineFluoresceinEx vivoGastroenterology
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Characterization of a Catalase-Negative Methicillin-Resistant Staphylococcus aureus Strain

2007

ABSTRACT We describe an unusual clinical strain of catalase-negative methicillin-resistant Staphylococcus aureus sensu stricto. Sequence analysis of its catalase gene showed 99.60% identities to the catalase genes of the reference strains. A 5-base deletion, however, led to a shift of the nucleotide reading frame and a loss of the enzymatic activity.

DNA BacterialMaleMicrobiology (medical)Staphylococcus aureusSequence analysisMolecular Sequence DataBiologymedicine.disease_causeStaphylococcal infectionsMicrobiologyparasitic diseasesmedicineHumansGeneAgedchemistry.chemical_classificationStrain (chemistry)BacteriologySequence Analysis DNAStaphylococcal InfectionsCatalasebacterial infections and mycosesmedicine.diseaseMethicillin-resistant Staphylococcus aureusEnzymechemistryStaphylococcus aureusCatalasebiology.proteinMethicillin ResistanceJournal of Clinical Microbiology
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Is cell salvage safe in liver resection? A pilot study

2007

Abstract Study Objective To investigate the quality of cell salvaged (CS) blood in patients undergoing hemihepatectomy (study group) and compare it with CS-blood from aortic surgery (control group). Design Observational study. Setting Operating room in a university hospital. Measurements 6 patients undergoing hemihepatectomy or aortobifemoral bypass with intraoperative blood loss of more than 800 mL. Samples were drawn from the central venous catheter, from the reservoir of a CS recovery system, and from the processed blood in each patient to determine interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor (TNF), complement C3a, and the terminal complement complex C5b-9. Microbiological ana…

medicine.medical_specialtyBlood transfusionmedicine.medical_treatmentCellPilot ProjectsComplement Membrane Attack ComplexResectionBlood Transfusion AutologousmedicineHepatectomyHumansInterleukin-6business.industryInterleukin-8InterleukinBacterial InfectionsInterleukin-10Complement systemSurgeryAnesthesiology and Pain Medicinemedicine.anatomical_structureCytokineComplement C3aErythrocyte TransfusionbusinessAnaerobic exerciseCentral venous catheterJournal of Clinical Anesthesia
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