6533b7d4fe1ef96bd1261fcd
RESEARCH PRODUCT
Amperometric Biosensor and Front-End Electronics for Remote Glucose Monitoring by Crosslinked PEDOT-Glucose Oxidase
Graziella ScandurraGino GiusiMichelangelo ScopellitiViviana FigaG. CannataBruno PignataroLuigi OcchipintiGiovanni MairaCarmine CiofiVincenzo VinciguerraYana Aleevasubject
polymer filmsWorking electrodeMonitoringElectrodeAmperometric sensors; biosensors; chemical and biological sensors; conductive films; polymer films; remote sensing; thick film biosensors; Instrumentation; Electrical and Electronic Engineering02 engineering and technologySubstrate (electronics)01 natural scienceschemical and biological sensorsconductive filmsChemical and biological sensorremote sensingPEDOT:PSSGlucose oxidaseSensitivity (control systems)SugarElectrical and Electronic EngineeringInstrumentationthick film biosensorsAmperometric sensorbiologySensor systembusiness.industryThick film biosensor010401 analytical chemistryConductive film021001 nanoscience & nanotechnologybiosensorsAmperometry0104 chemical sciencesElectrodebiology.proteinOptoelectronicsGoldPolymer filmAmperometric sensors0210 nano-technologybusinessBiosensorBiosensordescription
Focusing on the interplay between interface chemistry, electrochemistry, and integrated electronics, we show a novel low-cost and flexible biosensing platform for continuous glucose monitoring. The amperometric biosensing system features a planar three-electrode structure on a plastic substrate, and a wireless near-field communication-powered electronic system performing sensor analog front-end, A/D conversion, digital control, and display tasks. The working electrode is made of electropolymerized poly (3,4-ethylenedioxythiophene) film onto a polyethylene terephthalate/gold electrode followed by immobilization of cross-linked glucose oxidase by glutaraldehyde. The advantages offered by such a device, including low-cost materials and instrumentation as well as the good sensitivity of 9.24 $\mu \text{A}/({\mathrm {mM}} \cdot {\mathrm {cm}}^{2})$ are promising tools for point-of-care monitoring. It is demonstrated that the devices are good candidates for the development of advanced sensing approaches based on the investigation of the noise produced during operation (fluctuation-enhanced sensing).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 |