6533b7d4fe1ef96bd126264d
RESEARCH PRODUCT
Guaianolides from the Aerial Parts of Centaurea Hololeuca
Nelly A. ArnoldAntonella MaggioSergio RosselliMonique S. J. SimmondsRosa Angela RaccugliaMaurizio Brunosubject
0106 biological sciencesPharmacologybiologyChemistryPlant ScienceGeneral Medicinebiology.organism_classification010603 evolutionary biology01 natural sciencesComplementary and alternative medicineCentaureaDrug DiscoveryBotany010606 plant biology & botanydescription
Seven guaianolides were isolated from the acetone extract of the aerial parts of Centaurea hololeuca Boiss. The antifeedant activity of the natural compounds (1–7) and of four chloro derivatives (8–11), synthesized from repin (1) and janerin (3) were tested against larvae of Spodoptera littoralis. Cebellin J (6) and chlorojanerin (11) showed significant antifeedant activity at 100 ppm, whereas at this concentration cebellin G (4) and 15-deschloro-15-hydroxychlorojanerin (7) stimulated feeding. Cebellin G (4) stimulated larvae of S. littoralis to feed at low concentration, but deterred feeding at high concentrations. The addition of chlorine to repin (1) resulted in an increase in antifeedant activity.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-04-01 | Natural Product Communications |