Synthesis of 2-amino-6-(2-[18F]fluoro-pyridine-4-ylmethoxy)-9-(octyl-β-d-glucosyl)-purine: a novel radioligand for positron emission tomography studies of the O6-methylguanine-DNA methyltransferase (MGMT) status of tumour tissue

6533b7d4fe1ef96bd1262654

RESEARCH PRODUCT

Synthesis of 2-amino-6-(2-[18F]fluoro-pyridine-4-ylmethoxy)-9-(octyl-β-d-glucosyl)-purine: a novel radioligand for positron emission tomography studies of the O6-methylguanine-DNA methyltransferase (MGMT) status of tumour tissue

B Wängler Bernd Kaina Gerd Nagel Frank Rösch Esther Schirrmacher Jost Reinhard Manfred Wießler Ute Mühlhausen Markus Piel Ralf Schirrmacher

subject

Purine Methyltransferase medicine.diagnostic_test Organic Chemistry Conjugated system Biochemistry DNA methyltransferase digestive system diseases Tumour tissue chemistry.chemical_compound chemistry Biochemistry Positron emission tomography Drug Discovery Pyridine Radioligand medicine neoplasms

description

Abstract The synthesis of the novel glucose conjugated O6-methylguanine-DNA methyltransferase (MGMT) inhibitor 2-amino-6-(2-[18F]fluoro-pyridine-4-ylmethoxy)-9-(octyl-α- d -glucosyl)-purine is reported. This compound might serve as a radiotracer for the determination of the MGMT status of tumour tissue.

year	journal	country	edition	language
2002-09-01	Tetrahedron Letters

https://doi.org/10.1016/s0040-4039(02)01394-1

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