6533b7d4fe1ef96bd12628ae
RESEARCH PRODUCT
Stacking as a key property for creating nanoparticles with tunable shape: The case of squalenoyl-doxorubicin
Barbara StellaFranco DosioJean-philippe MichelDavid ChapronPatrick CouvreurClaudie BourgauxJulie MouginChristophe RamseyerSemen O. YesylevskyySemen O. Yesylevskyysubject
Materials scienceStackingGeneral Physics and AstronomyNanoparticleAntineoplastic AgentsNanotechnology02 engineering and technologysqualene010402 general chemistry01 natural sciencesbioconjugate; cylindrical nanoparticles; doxorubicin; elongated nanoparticles; nanomedicine; squalene; stackingdoxorubicinHydrophobic effectDrug Delivery Systemselongated nanoparticlespolycyclic compoundsGeneral Materials Sciencebioconjugatecylindrical nanoparticlesBioconjugationGeneral Engineering021001 nanoscience & nanotechnologynanomedicine3. Good health0104 chemical sciencesIonic strengthstackingDrug deliveryNanoparticlesNanomedicine0210 nano-technologyHydrophobic and Hydrophilic InteractionsConjugatedescription
The development of elongated nanoparticles for drug delivery is of growing interest in recent years, due to longer blood circulation and improved efficacy compared to spherical counterparts. Squalenoyl-doxorubicin (SQ-Dox) conjugate was previously shown to form elongated nanoparticles with improved therapeutic efficacy and decreased toxicity compared to free doxorubicin. By using experimental and computational techniques, we demonstrate here that the specific physical properties of SQ-Dox, which include stacking and electrostatic interactions of doxorubicin as well as hydrophobic interactions of squalene, are involved in the formation of nanoassemblies with diverse elongated structures. We show that SQ-Dox bioconjugate concentration, ionic strength, and anion nature can be used to modulate the shape and stiffness of SQ-Dox nanoparticles. As those parameters are involved in nanoparticle behavior in biological media, these findings could bring interesting opportunities for drug delivery and serve as an example for the design of original nanodrugs with stacking properties tuned for particular clinical purposes.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-01-01 | ACS Nano |