6533b7d4fe1ef96bd1262a86
RESEARCH PRODUCT
Goitrous congenital hypothyroidism in a twin pregnancy causing respiratory obstruction at birth: Implications for management
Andrew WattJoachim PohlenJudith SimpsonLena MacaraHaytham KubbaMalcolm DonaldsonBen C Reynoldssubject
medicine.medical_specialtyPediatricsGoiterThyroglobulinPregnancyPrenatal DiagnosisCongenital HypothyroidismDiseases in TwinsmedicineHumansTwin PregnancyPregnancyFetusThyroglobulin DeficiencyGoiterbusiness.industryInfant NewbornGestational ageGeneral MedicineAirway obstructionDelivery Obstetricmedicine.diseaseMagnetic Resonance ImagingSurgeryCongenital hypothyroidismAirway ObstructionPediatrics Perinatology and Child HealthFemalebusinessdescription
We report a twin pregnancy complicated by fetal goitrous hypothyroidism secondary to dyshormonogenesis caused by thyroglobulin deficiency. Antenatal treatment with intra-amniotic thyroxine was considered but not performed, given the late gestational age at diagnosis and the multiple nature of the pregnancy. Both twins developed airway obstruction at delivery, requiring intubation and ventilation. We review the literature and describe the practical issues relating to the antenatal assessment and perinatal management of fetal goitre.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2006-10-26 | Acta Paediatrica |