6533b7d4fe1ef96bd1262aa8
RESEARCH PRODUCT
Peripheral Neuropathy in the Hypereosinophilic Syndrome: A Case Report
V RodolicoR M CamardaD RaimondoO DanieleLupo Isubject
Pathologymedicine.medical_specialtyBiopsyAxonal losschemistry.chemical_compoundEosinophiliaBiopsymedicineHumansAxonmedicine.diagnostic_testHypereosinophilic syndromebusiness.industryPeripheral Nervous System DiseasesMiddle Agedmedicine.diseaseMast cellPeripheral neuropathymedicine.anatomical_structureNeurologychemistryImmunologyFemaleNeurology (clinical)businessVasculitisHistaminedescription
We observed a patient with the hypereosinophilic syndrome that showed as a prominent clinical feature peripheral nerve dysfunction. The neuropathy evolved over 4 months and affected sensory and motor functions. Nerve conduction studies and EMG were compatible with axonal neuropathy. Nerve and muscle biopsies revealed severe axonal degeneration with neurogenic atrophy of muscle. Morphometry of peroneal nerve showed marked axonal loss, more prominent in large myelinated fibers. There was no evidence of vasculitis process. Neuropathy is produced by eosinophil-released substances exerting a neurotoxic effect through direct altered vascular endothelial permeability and local mast cell histamine release.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-01-01 | European Neurology |