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RESEARCH PRODUCT

Impact of the SARS-CoV-2 Pandemic in Candidaemia, Invasive Aspergillosis and Antifungal Consumption in a Tertiary Hospital

Juan V Mulet BayonaBegoña Fuster EscriváMercedes Chanzá AviñóConcepción Gimeno CardonaCarme Salvador GarcíaNuria Tormo PalopPilar Ortega García

subject

Microbiology (medical)Antifungalmedicine.medical_specialtyCoronavirus disease 2019 (COVID-19)medicine.drug_classQH301-705.5Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)IFIPlant ScienceAspergillosisArticle03 medical and health sciences0302 clinical medicineInternal medicinePandemicmedicinecandidaemiaaspergillosis030212 general & internal medicineBiology (General)skin and connective tissue diseasesEcology Evolution Behavior and SystematicsVoriconazole0303 health sciences030306 microbiologybusiness.industryMortality rateisavuconazoleCOVID-19medicine.diseaserespiratory tract diseasesCandida aurisbusinessantifungalsmedicine.drug

description

In addition to the increase in fungal infections that has been observed in the last few decades, it has been reported that severe clinical COVID-19 can increase the risk of invasive fungal infections. The main objective of this study was to evaluate if there had been an increase in candidaemia and invasive pulmonary aspergillosis (IPA) cases since the onset of the SARS-CoV-2 pandemic. Data were retrospectively collected from April 2019 to March 2021, from patients admitted to Consorcio Hospital General Universitario de Valencia (Spain). A total of 152 candidaemia cases (56 of which were due to Candida auris) and 108 possible IPA cases were detected. A great increase in candidaemia cases was produced during the first and the third epidemic waves of the SARS-CoV-2 pandemic (June 2020, and January 2021, respectively), while an increase in IPA cases was produced during the third wave. The 28-day mortality rates in patients affected by candidaemia and IPA increased in 2020 and 2021. C. auris has displaced the other Candida species, becoming the most isolated Candida species in blood cultures since the onset of the SARS-CoV-2 pandemic. Antifungal consumption increased in 2020 when compared to 2019, especially echinocandins, voriconazole and isavuconazole.

yearjournalcountryeditionlanguage
2021-05-01Journal of Fungi
10.3390/jof7060440http://europepmc.org/articles/PMC8228091