6533b7d4fe1ef96bd12633c8
RESEARCH PRODUCT
Evoked potential study in facio-scapulo-humeral muscular dystrophy.
Filippo BrighinaBrigida FierroD. BuffaA. AloisioMassimiliano OliveriV. La BuaOrnella DanieleL. Manfresubject
AdultMalemedicine.medical_specialtyShoulderNeural ConductionSensory systemSomatosensory systemSeverity of Illness IndexNerve conduction velocityMuscular DystrophiesWhite matterInternal medicineEvoked Potentials SomatosensorymedicineEvoked Potentials Auditory Brain StemHumansMuscular dystrophyAuditory Diseases CentralSubclinical infectionChi-Square DistributionDystrophyBrainGenetic VariationGeneral MedicineMiddle Agedmedicine.diseaseMagnetic Resonance ImagingMedian Nervemedicine.anatomical_structureNeurologySomatosensory evoked potentialCase-Control StudiesFaceCardiologyArmFemaleNeurology (clinical)Tibial NervePsychologyNeurosciencedescription
Nerve conduction velocities (NCVs), somatosensory (SEPs) and auditory evoked potentials (BAEPs) were recorded in 9 patients with facio-scapulo-humeral dystrophy (FSHD) and in 20 age-matched controls. In FSHD patients a significant increase of the nerve distal sensory latencies and of the absolute SEP latencies revealed a subclinical involvement of the afferent sensory pathways, as well as the abnormal slowing of the later components of the BAEPs, pointed to a central auditory dysfunction. Moreover all patients underwent brain MRI that showed the presence of white matter hyperintense lesions in 4 of them (44%). No correlations were found between individual or total number of SEP and BAEP abnormal electrophysiological parameters and severity of WMHL, age, age at onset, duration of the disease or muscular impairment. These findings make the interpretation and pathophysiology of the nervous damage in FSHD rather uncertain. More studies are required to better define the aspects of neurogenic involvement in this type of muscular dystrophy.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-06-01 | Acta neurologica Scandinavica |