6533b7d4fe1ef96bd1263481

RESEARCH PRODUCT

Curvature increases permeability of the plasma membrane for ions, water and the anti-cancer drugs cisplatin and gemcitabine

Christophe RamseyerSemen O. YesylevskyySemen O. YesylevskyyTimothée Rivel

subject

Cell Membrane PermeabilityLipid Bilayerslcsh:MedicineAntineoplastic AgentsMolecular Dynamics SimulationCurvature01 natural sciencesDeoxycytidineArticleSupramolecular assemblyIonMembrane bending03 medical and health sciencesComputational biophysics0103 physical sciencesmedicineAnimalsHumanslcsh:Science030304 developmental biologyCisplatinIons0303 health sciences010304 chemical physicsChemistryCell Membranelcsh:RWaterMembrane structure and assemblyGemcitabineOrders of magnitude (mass)MembraneMembrane curvaturePermeability (electromagnetism)Drug deliveryBiophysicslcsh:QCisplatinmedicine.drug

description

ABSTRACTIn this work the permeability of a model asymmetric plasma membrane, for ions, water and the anti-cancer drugs cisplatin and gemcitabine is studied by means of all-atom molecular dynamics simulations. It is shown that permeability of the membranes increases from one to three orders of magnitude upon membrane bending depending on the compound and the sign of curvature. Our results show that the membrane curvature is an important factor which should be considered during evaluation of drug translocation.TOC GRAPHICS

yearjournalcountryeditionlanguage
2019-04-08Scientific Reports
10.1038/s41598-019-53952-2http://dx.doi.org/10.1038/s41598-019-53952-2