6533b7d4fe1ef96bd1263482

RESEARCH PRODUCT

Unprecedented new nonadecylpara-hydroperoxycinnamate isolated fromErythrina excelsaand its cytotoxic activity

Augustin Ephrem NkengfackVictor KueteAnaelle A.k. WandjaThomas EfferthSimplice B. TankeoLouis P. SandjoGuy M.n. Kwamou

subject

Magnetic Resonance SpectroscopyStereochemistryPlant ScienceBiochemistryMass SpectrometryAnalytical Chemistrychemistry.chemical_compoundCell Line TumorHumansIsoneorautenolCytotoxic T cellErythrinaErythrinaLupeolStigmasterolMolecular StructurebiologyPlant ExtractsOrganic ChemistryFabaceaeAntimicrobialbiology.organism_classificationAntineoplastic Agents PhytogenicAnti-Bacterial AgentschemistryCinnamatesPlant BarkDrug Screening Assays AntitumorDerivative (chemistry)

description

A new unprecedented cinnamate derivative (1) was obtained from Erythrina excelsa (Leguminosae) and identified as nonadecyl para-hydroperoxycinnamate. This compound was isolated together with three known compounds, namely lupeol (2), mixture of sitosterol and stigmasterol (3), and isoneorautenol (4). Their structures were established on the basis of NMR and mass spectroscopic data in conjunction with those reported in the literature. Compound 1 was evaluated for its capability of inhibiting cancer cell lines and growth of a panel of microbial strains. It turned out that 1 is moderately to significantly cytotoxic against six cancer cell lines and shows weak to no antimicrobial activity.

yearjournalcountryeditionlanguage
2014-09-16Natural Product Research
https://doi.org/10.1080/14786419.2014.959519