6533b7d5fe1ef96bd1263f68

RESEARCH PRODUCT

TAP-polymorphisms in juvenile onset psoriasis and psoriatic arthritis.

Rudolf E. SchopfChristian RittnerElisabeth Märker-hermannArndt WeinmannPeter HasencleverKarl-h. Meyer Zum BüschenfeldeThomas HöhlerPeter M. SchneiderJürgen Knop

subject

ImmunologyLinkage DisequilibriumMajor Histocompatibility ComplexPsoriatic arthritisATP Binding Cassette Transporter Subfamily B Member 3PsoriasismedicineImmunology and AllergyHumansPsoriasisAlleleATP Binding Cassette Transporter Subfamily B Member 2GenePolymorphism Geneticbiologybusiness.industryEndoplasmic reticulumArthritis PsoriaticHistocompatibility Antigens Class IGeneral MedicineTransporter associated with antigen processingHLA-DR Antigensmedicine.diseaseImmunologybiology.proteinTAP2ATP-Binding Cassette TransportersTAP1business

description

Abstract Juvenile onset psoriasis is strongly associated with the HLA-class I genes Cw6 and B57 whereas patients with psoriatic arthritis show an increased frequency of HLA-B27. It is unclear whether additional major histocompatibility genes also increase disease susceptibility. The TAP genes (transporter associated with antigen processing) encode two membrane-spanning proteins that translocate antigenic peptides from the cytoplasm into the endoplasmic reticulum. Comparison of 60 patients with juvenile onset psoriasis, 63 psoriatic arthritis patients, and 101 caucasoid controls revealed an increase of the TAP1 ∗ 0101 allele in the psoriasis group, that could not be explained by linkage to other investigated HLA genes. There were no differences for TAP2 alleles.

yearjournalcountryeditionlanguage
1996-11-01Human immunology
10.1016/s0198-8859(96)00156-5https://pubmed.ncbi.nlm.nih.gov/8911997