6533b7d5fe1ef96bd1264539

RESEARCH PRODUCT

Hollow Polymeric Capsules from POSS-Based Block Copolymer for Photodynamic Therapy

Yudong XueAxel H. E. MüllerWeian ZhangPengcheng ZhangZhenghe Zhang

subject

Materials sciencePolymers and PlasticsOrganic ChemistryChain transfer02 engineering and technologyRaft010402 general chemistry021001 nanoscience & nanotechnologyMethacrylate01 natural sciencesMicelleSilsesquioxane0104 chemical sciencesInorganic Chemistrychemistry.chemical_compoundMonomerPolymerizationchemistryPolymer chemistryMaterials ChemistryCopolymer0210 nano-technology

description

A novel amphiphilic diblock copolymer, PHEMAPOSS-b-P(DMAEMA-co-CMA), was prepared via reversible addition–fragmentation chain transfer (RAFT) polymerization, where PHEMAPOSS block was first synthesized using a methacrylate monomer based on polyhedral oligomeric silsesquioxane (HEMAPOSS), and PHEMAPOSS was further utilized to prepare the block copolymer via RAFT copolymerization of 2-(dimethylamino)ethyl methacrylate (DMAEMA) and reduction-cleavable coumarin methacrylate (CMA) monomer. PHEMAPOSS-b-P(DMAEMA-co-CMA) could self-assemble in water to form spherical micelles with POSS core and stimuli-responsive shell. The micelles were cross-linked by photodimerization of coumarin, and then hollow polymeric capsules could be finally obtained via etching the POSS core in the solution of hydrofluoric acid (HF). The morphologies of the micelles and hollow polymeric capsules were well characterized by TEM, SEM, and DLS. The hollow polymeric capsules are responsive to typical physiological stimuli such as pH, and re...

yearjournalcountryeditionlanguage
2016-11-11Macromolecules
https://doi.org/10.1021/acs.macromol.6b02414