6533b7d5fe1ef96bd1264646

RESEARCH PRODUCT

Hyperbranched polyethylenimine-supported copper(II) ions as a macroliganted homogenous catalyst for strict click reactions of azides and alkynes in water

Hicham Ben El AyouchiaLahoucine BahsisMiguel JulveHamid ElmouliHafid AnaneSalah-eddine StiribaCarlos J. Gómez-garcíaRachid Laamari

subject

chemistry.chemical_classificationPolyethylenimine010405 organic chemistryReducing agentChemistryOrganic ChemistryRegioselectivitychemistry.chemical_elementHomogeneous catalysisPolymer010402 general chemistry01 natural sciencesBiochemistryCopperCycloaddition0104 chemical sciencesCatalysisInorganic Chemistrychemistry.chemical_compoundPolymer chemistryMaterials ChemistryPhysical and Theoretical Chemistry

description

Abstract Loading hyperbranched polyethylenimine (PEI) with copper(II) ions leads to the formation of a new water-soluble metallodendritic polymer Cu(II)-PEI that has been found to effectively catalyze the clickable azide-alkyne [3 + 2] cycloaddition reactions in water under ambient conditions, in the lack of any external reducing agent. A positive dendritic effect on the catalyst activity was observed in the click of 1,2,3-triazole by lowering the reduction potential of copper(II) into the in-situ generation of the catalytically active species copper(I). The reaction proceeds straightforwardly to afford the corresponding 1,4-disubstituted-1,2,3-triazole derivatives in a regioselective manner. The precatalystCu(II)-PEI has been easily recovered and reused for up to ten-sequential applications with a decrease in its catalytic activity.

yearjournalcountryeditionlanguage
2019-10-01Journal of Organometallic Chemistry
https://doi.org/10.1016/j.jorganchem.2019.120881