Risk of laryngeal edema and facial swellings after tooth extraction in patients with hereditary angioedema with and without prophylaxis with C1 inhibitor concentrate: a retrospective study.

6533b7d5fe1ef96bd12648d6

RESEARCH PRODUCT

Risk of laryngeal edema and facial swellings after tooth extraction in patients with hereditary angioedema with and without prophylaxis with C1 inhibitor concentrate: a retrospective study.

Konrad Bork Petra Staubach-renz Jochen Hardt Guenther Witzke

subject

Larynx Adult Male medicine.medical_specialty Time Factors Premedication Complement C1 Inactivator Proteins Laryngeal Edema Chemoprevention C1-inhibitor Risk Factors Edema medicine Edema Humans Risk factor General Dentistry Retrospective Studies biology Dose-Response Relationship Drug business.industry Angioedemas Hereditary Retrospective cohort study Laryngeal Edema medicine.disease Surgery medicine.anatomical_structure Treatment Outcome Otorhinolaryngology Face Hereditary angioedema Injections Intravenous Tooth Extraction biology.protein Surgery Premedication Female Oral Surgery medicine.symptom business Complement C1 Inhibitor Protein Follow-Up Studies

description

Objective Tooth extractions may trigger clinical symptoms of hereditary angioedema due to C1 inhibitor deficiency (HAE-C1-INH). The aim of this study was to determine how many tooth extractions were followed by symptoms of HAE-C1-INH in patients with and without preoperative short-term prophylaxis with C1 inhibitor concentrate. Study design Tooth extractions and clinical symptoms of HAE-C1-INH were determined from clinical record files of 171 patients with HAE-C1-INH. Results Facial swelling or potentially life-threatening laryngeal edema, or both, occurred in 124/577 tooth extractions (21.5%) without prophylaxis. Similar symptoms occurred in a fewer proportion of patients undergoing extractions (16/128; 12.5%) after short-term prophylaxis with C1 inhibitor concentrate. The graded dose-response relationship was significant at P Conclusions Short-term prophylaxis with C1 inhibitor concentrate significantly reduces the risk of HAE-C1-INH symptoms after tooth extraction. In some patients, however, facial swellings and laryngeal edema symptoms may occur despite prophylaxis.

year	journal	country	edition	language
2010-10-05	Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics

10.1016/j.tripleo.2011.02.034 https://pubmed.ncbi.nlm.nih.gov/21601496