6533b7d5fe1ef96bd1264d5a

RESEARCH PRODUCT

Assembly of Polycomb complexes and silencing mechanisms

Pirrotta VincenzoPoux SylvainMelfi RaffaellaPilyugin Maxim

subject

DNA-Binding ProteinsPolycomb Repressive Complex 1AnimalsDrosophila ProteinsDrosophilaSettore BIO/11 - Biologia MolecolareGene SilencingChromatin silencingChromatinChromatin memoryTranscription FactorsPolycomb complexes

description

Polycomb complexes assemble at their target sites and silence neighboring genes when these are not actively transcribed. The action of these complexes and of Trithorax complexes bound to the Polycomb Response Element establish alternative silent or derepressed states that are remembered through cell division and maintained for the rest of development. Recent results that may help explain the properties of these states are reviewed.

yearjournalcountryeditionlanguage
2003-05-02
10.1023/a:1022992011833https://hdl.handle.net/10447/587490