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RESEARCH PRODUCT

The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies

Brendon StubbsMichele FornaroMarco SolmiNicola VeroneseKamilla W. MiskowiakCristiano A. KöhlerRodrigo Machado-vieiraLícia Pacheco PereiraAndré F. CarvalhoBárbara P. De Freitas FreitasRafael T. De SousaVieta Eduard

subject

Transtorno BipolarCandidate genediffusion tensor imagingvoxel based morphometryBipolar disorderBipolar disorder Genetic polymorphisms Neuroimaging Magnetic resonance imaging Functional MRI Diffusion tensor imagingvoxel based morphometryCognitive NeuroscienceBrain Structure and FunctionGenome-wide association studyNeuroimagingComputational biologyGenetic polymorphismsFaculty of Social Sciences03 medical and health sciencesDISC1Behavioral Neuroscience0302 clinical medicineMagnetic resonance imagingNeuroimaginggenetic polymorphisms/dk/atira/pure/core/keywords/FacultyOfSocialSciencesImatges per ressonància magnèticamedicineHumansManic-depressive illnessANK3Bipolar disorderCervellNeuroimagemDiffusion tensor imagingvoxel based morphometryFunctional MRIGenetic polymorphismneuroimagingTrastorn bipolarbiologyBipolar disorder; Diffusion tensor imagingvoxel based morphometry; Functional MRI; Genetic polymorphisms; Magnetic resonance imaging; Neuroimaging; Neuropsychology and Physiological Psychology; Cognitive Neuroscience; Behavioral NeuroscienceReproducibility of ResultsBrainmedicine.disease030227 psychiatryNeuropsychology and Physiological Psychology5-HTTLPRbiology.proteinfunctional MRIImagem por Ressonância MagnéticaPsychologyNeuroscience030217 neurology & neurosurgeryHumanGenome-Wide Association Study

description

Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N = 2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach. © 2017 Elsevier Ltd

yearjournalcountryeditionlanguage
2017-08-01
http://hdl.handle.net/2445/125372