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RESEARCH PRODUCT
Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial
Anna Tresserra-rimbauEnrique Gómez-graciaMiquel FiolJordi Salas-salvadóJosé LapetraZenaida Vázquez-ruizZenaida Vázquez-ruizJosé V SorlíJosé V. SorlíEmilio SacanellaRamon EstruchMontserrat CofánMontserrat CofánOlga CastañerÁNgel M. Alonso-gómezÁNgel M. Alonso-gómezCamille LassaleÁLvaro HernáezSara Castro-barqueroSara Castro-barqueroCristina RazquinCristina RazquinXavier PintóDolores CorellaDolores CorellaLluis Serra-majemLluis Serra-majemMarta Guasch-ferréMarta Guasch-ferréEmilio RosEmilio Rossubject
Male0301 basic medicineMediterranean dietthrombocytopenia030204 cardiovascular system & hematologyDiet Mediterraneanlaw.inventionClinical trials0302 clinical medicinepreventionRandomized controlled triallawPlateletThrombocytosisNutrition and DieteticsFactors de risc en les malaltiesIncidenceIncidence (epidemiology)Hazard ratioFemaleDietalcsh:Nutrition. Foods and food supplymedicine.medical_specialtyRisk factors in diseaseslcsh:TX341-641ArticleOlder population03 medical and health sciencesMediterranean cookingMediterranean dietInternal medicineCuina mediterràniamedicineHumansAgedProportional Hazards ModelsThrombocytosisPlatelet Countbusiness.industryplatelet countmedicine.diseaseConfidence intervalDiet030104 developmental biologyHeart Disease Risk Factorsrandomized controlled trialbusinessAssaigs clínicsFood Sciencedescription
There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-08 | Nutrients |