6533b7d5fe1ef96bd1265226
RESEARCH PRODUCT
Brain responses to sound intensity changes dissociate depressed participants and healthy controls.
Piia AstikainenElisa M. Ruohonensubject
masennusBrain activationAdultMalemedicine.medical_specialtyAdolescentdepression (mental disorders)Mismatch negativitySensory systempsychologyAudiologySerotonergicDevelopmental psychologysound intensity03 medical and health sciencesYoung Adult0302 clinical medicineHealthy controlmedicineHumanspre-attentive processingta515Depression (differential diagnoses)MMNDepressive Disorder MajorPre-attentive processingGeneral Neuroscienceauditory perceptionsBrainN1ElectroencephalographyMiddle AgedSound intensity030227 psychiatryäänenvoimakkuusNeuropsychology and Physiological PsychologySoundAcoustic StimulationCase-Control StudiesAuditory PerceptionEvoked Potentials AuditorypsykologiaFemalePsychologyERP030217 neurology & neurosurgerydescription
Depression is associated with bias in emotional information processing, but less is known about the processing of neutral sensory stimuli. Of particular interest is processing of sound intensity which is suggested to indicate central serotonergic function. We tested weather event-related brain potentials (ERPs) to occasional changes in sound intensity can dissociate first-episode depressed, recurrent depressed and healthy control participants. The first-episode depressed showed larger N1 amplitude to deviant sounds compared to recurrent depression group and control participants. In addition, both depression groups, but not the control group, showed larger N1 amplitude to deviant than standard sounds. Whether these manifestations of sensory over-excitability in depression are directly related to the serotonergic neurotransmission requires further research. The method based on ERPs to sound intensity change is fast and low-cost way to objectively measure brain activation and holds promise as a future diagnostic tool. acceptedVersion Peer reviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-07-01 | Biological psychology |