Wirkungsspektrum des C¯1-Inaktivators aus Meerschweinchenserum

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Wirkungsspektrum des C¯1-Inaktivators aus Meerschweinchenserum

subject

Microbiology (medical)media_common.quotation_subject Immunology Immunology and Allergy General Medicine Art Molecular biology media_common

description

Es wird die Wirkungsweise des C¯1-Inaktivators (I1) gegenuber C¯1 und dem C4 umsetzenden Protein der Euglobulinfraktion (I4) beschrieben. Zum Nachweis der C¯1-Aktivitat wurden vier Nachweismoglichkeiten herangezogen: Die Titration der hamolytischen Wirkung, die Beurteilung des Umsatzes von C4 und C2, sowie die esterolytische Aktivitat gegenuber TAMe. Alle vier Aktivitaten des C¯1 werden durch I1 gehemmt. Daraus ist zu schliesen, das C¯1 eine einheitliche Wirkung ausubt. Diese wird in den Testsystemen in verschiedener Form nachweisbar. Die I4-Aktivitat wird durch I1 in gleicher Form gehemmt wie die C¯1-Aktivitat. Dies spricht fur die Identitat von I4 und der enzymatisch aktiven Untereinheit des C¯1.

year	journal	country	edition	language
1971-03-01	Zeitschrift für Medizinische Mikrobiologie und Immunologie

https://doi.org/10.1007/bf02124651

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