6533b7d6fe1ef96bd1265bd9

RESEARCH PRODUCT

WT1 isoform expression pattern in acute myeloid leukemia.

Pascual BoluferMaría López-pavíaDavid Martínez-cuadrónJosé CerveraOscar FusterMiguel A. SanzPau MontesinosMariam IbáñezMarta LlopSandra DolzIrene LunaEva BarragánEsperanza SuchFederico MoscardóInés Gómez-seguíCarmen AlonsoM. Leonor SenentSilvestre OltraIgnacio LorenzoBelén Vera

subject

Gene isoformAdultMalecongenital hereditary and neonatal diseases and abnormalitiesCancer ResearchAdolescentCD34HL-60 CellsBiologyurologic and male genital diseasesPositive correlationCohort StudiesYoung AdultDual roleExpression patternhemic and lymphatic diseasesmedicineTumor Cells CulturedHumansProtein IsoformsWT1 ProteinsAgedAged 80 and overurogenital systemGene Expression Regulation LeukemicGene Expression ProfilingMyeloid leukemiaHematologyMiddle Agedmedicine.diseaseMolecular biologyfemale genital diseases and pregnancy complicationsLeukemiaLeukemia Myeloid AcuteOncologyCase-Control StudiesFemaleK562 Cells

description

WT1 plays a dual role in leukemia development, probably due to an imbalance in the expression of the 4 main WT1 isoforms. We quantify their expression and evaluate them in a series of AML patients. Our data showed a predominant expression of isoform D in AML, although in a lower quantity than in normal CD34+ cells. We found a positive correlation between the total WT1 expression and A, B and C isoforms. The overexpression of WT1 in AML might be due to a relative increase in A, B and C isoforms, together with a relative decrease in isoform D expression.

yearjournalcountryeditionlanguage
2013-05-10Leukemia research
10.1016/j.leukres.2013.10.009https://pubmed.ncbi.nlm.nih.gov/24211094