6533b7d6fe1ef96bd1265d9f

RESEARCH PRODUCT

Aggregation of sponge cells. Isolation and characterization of an inhibitor of aggregation receptor from the cell surface.

Werner E.g. MüllerRudolf K. ZahnIsabel M. MüllerP. VaithBranko KurelecGerd Uhlenbruck

subject

chemistry.chemical_classificationbiologyCellCell MembraneGuanosine MonophosphateMembrane ProteinsCarbohydratebiology.organism_classificationBiochemistryPoriferaMolecular WeightSpongeKineticsMembranemedicine.anatomical_structurechemistryBiochemistrymedicineMoleculeAnimalsGeodiaGlycoproteinReceptorCell Aggregation

description

From the cell membranes of the sponge Geodia cydonium a component was isolated and purified which inhibits the aggregation factor isolated from the same source; the component was termed anti-aggregation receptor. This molecule was characterized as a glycoprotein (54% neutral carbohydrate) and its molecular weight is in the range of 180,000 One biological site of the anti-aggregation receptor was determined to be D-galactose. Indirect evidence presented seems to indicate that this molecule is present in an active form in aggregation-deficient cells and absent in aggregation-susceptible cells.

yearjournalcountryeditionlanguage
1979-07-01European journal of biochemistry
10.1111/j.1432-1033.1979.tb13147.xhttps://pubmed.ncbi.nlm.nih.gov/223844