6533b7d6fe1ef96bd1265deb
RESEARCH PRODUCT
Treatment with essential amino acids in patients on chronic hemodialysis: a double blind cross-over study.
Winfried PrellwitzH. MaderMüller DWolfgang OpferkuchZobel RH J KeimHecking EE M LemmelKöhler Hsubject
AdultMalemedicine.medical_specialtymedicine.medical_treatmentMedicine (miscellaneous)PhenylalanineComplement factor Ichemistry.chemical_compoundGlomerulonephritisRenal DialysisInternal medicineProtein DeficiencyMedicineHumansPrealbuminchemistry.chemical_classificationClinical Trials as TopicNutrition and DieteticsPyelonephritisbusiness.industryTransferrinComplement C3Middle Agedmedicine.diseaseCrossover studyAmino acidRetinol-Binding ProteinsMalnutritionEndocrinologychemistryBiochemistryUreaUric acidFemaleHemodialysisAmino Acids Essentialbusinessdescription
Patients on chronic hemodialysis may suffer from a latent protein deficiency, and therapy with essential amino acids has been recommended. In a double blind cross-over study, 13 hemodialysis patients received orally 15.7 g of essential amino acids daily over a 3-month period. Patients were on a liberal diet, containing 1 g of protein per kilogram of body weight per day. Hemodialysis was adequate. Therapy resulted in an increase in urea, uric acid, C3 c complement factor and a fall in C4. Lysine levels increased and phenylalanine fell. Malnutrition could not account for the observed metabolic changes, which are more likely due to uremic metabolic disturbances. A liberal diet of 1 g of protein per kilogram of body weight appears sufficient for patients on hemodialysis. Treatment with essential amino acids offers no advantage.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1978-10-01 | The American journal of clinical nutrition |