6533b7d6fe1ef96bd1265e69

RESEARCH PRODUCT

Prognostic outcome of routine clinical noninvasive Multidetector row Computed Tomography Coronary Angiography in Patients with suspected coronary artery disease: a 2-years follow-up study.

Ludovico La GruttaG RunzaGiovanni Domenico GentileEmanuela RussoGiuseppe Lo ReMassimo GaliaTommaso Vincenzo BartolottaV AlaimoR MalagòF CademartiriAdelfio CardinaleMassimo MidiriGiuseppe Lo Re

subject

Coronary angiographyMaleMalattia aterosclerotica coronaricamedicine.medical_specialtyContext (language use)Coronary Artery DiseaseCoronary AngiographySensitivity and SpecificityCoronary artery diseasePredictive Value of TestsInternal medicinemedicineImage Processing Computer-AssistedHumansRadiology Nuclear Medicine and imagingIn patientValore prognosticocardiovascular diseasesCoronary artery disease Prognostic value Coronary angiography Multidetector row computed tomographyNeuroradiologymedicine.diagnostic_testbusiness.industryFollow up studiesInterventional radiologyGeneral MedicineMultidetector row computed tomographyMiddle Agedmedicine.diseasePrognosisPredictive value of testsAngiografia coronaricacardiovascular systemCardiologyFemaleRadiologyTomografia computerizzata multistratobusinessTomography X-Ray ComputedSettore MED/36 - Diagnostica Per Immagini E RadioterapiaPrognostic value

description

The aim of the study was to assess the prognostic value of multidetector-row CT coronary angiography (MDCT-CA) in patients with suspected coronary artery disease (CAD) in a routine clinical context.A total of 125 patients (82 men, age 57.4±10.3 years) with suspected CAD underwent MDCT-CA. All patients were assessed for cardiovascular risk factors, symptoms and coronary calcium score. A 2-year follow-up study for the occurrence of major adverse cardiac events was performed.According to the Morise pretest score, 76 patients (60.8%) were at intermediate risk. Patients with suspected CAD presented the following prognostic outcome (p0.0001): in 41 patients with normal coronary arteries at MDCT-CA, the event rate was 0%; five of 49 patients with nonobstructive CAD had major cardiac events; two of 35 patients with obstructive CAD suffered cardiac death and 19 underwent revascularisation. At multivariate analysis, the presence of obstructive CAD is the only significant independent prognostic variable (hazard ratio, 10.1393; 95% confidence interval 3.2189-31.9379; p0.0001).Routine clinical MDCT-CA provides an excellent prognostic value at 2-year follow-up in patients with normal coronary arteries. The cardiac event rate increases with CAD severity.

yearjournalcountryeditionlanguage
2011-01-01
10.1007/s11547-011-0655-zhttp://hdl.handle.net/10447/59301