6533b7d6fe1ef96bd12664b8
RESEARCH PRODUCT
Structural characterisation and nuclease activity of mixed copper(II) complexes with sulfonamides and bipyridil
Isabel Garcı́aMaría V. VillaMarta González-álvarezBenigno MacíasJoaquín BorrásAlfonso Castiñeirassubject
NucleasebiologyChemistrychemistry.chemical_elementCopperlaw.inventionInorganic ChemistryElectrophoresisCrystallographychemistry.chemical_compoundBipyramidlawMaterials Chemistrybiology.proteinPhysical and Theoretical ChemistryFourier transform infrared spectroscopyElectron paramagnetic resonanceHydrogen peroxideSingle crystaldescription
Mixed copper complexes have been synthetised through reaction of Cu(II) salts with bipyridil and N-quinolin-8-yl-p-toluenesulfonamide (Hqtsa), N-quinolin-8-yl-benzenesulfonamide (Hqbsa) or N-quinolin-8-yl-naftalenesulfonamide (Hqnsa). Single crystal X-ray diffraction structure determination shows that copper cations are five-coordinated, one complex have distorted bipyramidal trigonal geometry and the other have a distorted square-pyramid. The FT IR and EPR spectra are also reported. Electrophoresis results show that the synthetised complexes in the presence of ascorbate and hydrogen peroxide are chemical nucleases.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-09-01 | Inorganica Chimica Acta |