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RESEARCH PRODUCT
Effect of isoprinosine on IL-2, IFN-γ and IL-4 production in vivo and in vitro
Stephanie MillottEnrico CillariMaria DieliElvira MalteseSalvatore MilanoM.dora Micelisubject
Interleukin 2medicine.drug_classImmunologyIn Vitro TechniquesBiologyImmunostimulantInterferon-gammaMiceT-Lymphocyte SubsetsIn vivoInosine PranobexmedicineSplenocyteAnimalsInterferon gammaReceptorInterleukin 4PharmacologyMice Inbred BALB CIn vitroImmunologyInterleukin-2FemaleInterleukin-3Interleukin-4Spleenmedicine.drugdescription
The effects of an immunopotentiating drug, isoprinosine, on the splenocytes of BALB/c mice to produce cytokines were investigated. Isoprinosine enhanced IL-2 production, upregulating the expression of IL-2 receptor in vitro. It also significantly increased the IFN-gamma secretion and decreased the IL-4 production in vivo. The significance of these findings in terms of immune regulation is discussed.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-01-01 | International Journal of Immunopharmacology |