6533b7d6fe1ef96bd1267026
RESEARCH PRODUCT
Harnessing medically relevant metals onto water-soluble subphthalocyanines: towards bimodal imaging and theranostics
Pascale WincklerJean-marie Perrier-cornetRichard A. DecréauYann Bernhardsubject
IndolesMagnetic Resonance SpectroscopyFluorophoregenetic structuresCell SurvivalGadoliniumMelanoma ExperimentalAnalytical chemistrychemistry.chemical_elementIsoindolesConjugated system010402 general chemistry01 natural sciencesInorganic ChemistryMetalchemistry.chemical_compoundCell Line TumorMicroscopyHumans[CHIM]Chemical SciencesDOTA010405 organic chemistryWaterFluorescence0104 chemical sciencesSolubilitychemistryMetalsvisual_artvisual_art.visual_art_mediumNuclear chemistryConjugatedescription
International audience; Subphthalocyanine (SubPc), a putative fluorophore for optical imaging (OI), was conjugated to chelating ligands (DOTA, DTPA) affording water-soluble conjugates complexed with (non-radioactive) metals relevant to the following medical imaging techniques/therapies: MRI (Gd), PET (Cu, Ga), SPECT (In, Ga, Lu), RIT (Cu, Lu, Y), and NCT (Gd). Magneto-optical properties of ditopic gadolinium species (and optical properties of other metal containing species) were examined (brightness (ε × Φ F) and relaxivity R 1) and fluorescence confocal/biphoton microscopy studies were conducted. † Electronic supplementary information (ESI) available: Experimental characterization, NMR and photophysical spectra. See
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-12-22 | Dalton Transactions |