6533b7d6fe1ef96bd126709a

RESEARCH PRODUCT

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations

Juan TamargoConrado J. CalvoConrado J. CalvoConrado J. CalvoRaul BenitezRicardo CaballeroGabriela Guzmán-martínezGabriela Guzmán-martínezNuria CabelloCarlos López-otínDavid Filgueiras-ramaDavid Filgueiras-ramaAdela Herraiz-martínezVicente AndrésFernando G. OsorioJuan Antonio GuadixEva DelpónJosé Rivera-torresJosé M. Pérez-pomaresJosé JalifeJosé JalifeLeif Hove-madsenLuis Jesús Jiménez-borregueroAnna LlachCristina González-gómezAlexander VallmitjanaLeslie B. GordonLeslie B. Gordon

subject

0301 basic medicineMaleHutchinson–Gilford progeria syndrome calcium handling connexin43 prelamin A progerinElectrònica en cardiologia030204 cardiovascular system & hematologyPathogenesisCiencias Biomedicas0302 clinical medicineProgeriaCardiac Conduction System DiseasefisiologiapatologíaTecnología médicaChildCiencias médicasMice KnockoutProgeriaprelamin AMultidisciplinaryintegumentary systemMetalloendopeptidasesHeartProgerinHutchinson-Gilford progeria syndrome3. Good health:Enginyeria biomèdica::Electrònica biomèdica::Electrònica en cardiologia [Àrees temàtiques de la UPC]Sarcoplasmic Reticulummedicine.anatomical_structurePNAS PlusChild Preschoolcardiovascular systemNuclear laminaFemalemedicine.symptomBradycardiaAdultmedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesAdolescentBiology03 medical and health sciencesQRS complexYoung AdultElectrònica mèdicaInternal medicinemedicineAnimalsHumansPR intervalHutchinson–Gilford progeria syndromeNuclear LaminaMyocardiumMembrane Proteinsnutritional and metabolic diseasesArrhythmias Cardiacmedicine.diseaseMedical electronicsconnexin43Mice Inbred C57BL030104 developmental biologyEndocrinologyVentricleprogerinConnexin 43calcium handlingsistema cardiovascularCalcium

description

This work was supported by Spanish Ministry of Economy and Competitiveness (MINECO) Grants SAF2010-16044 and SAF2013-46663-R (to V.A.), SAF2011-30312 and SAF2014-58286-C2-1-R (to L.H.-M.), SAF2011-30088 (to E.D.), and SAF2014-52413-R (to C.L.-O.) and Fondo de Investigación Sanitaria del Instituto de Salud Carlos III Grants RD12/0042/0028 (to V.A.), RD12/0042/0011 (to J.T.), and RD12/0042/0002 (to L.H.-M.), with cofunding from the Fondo Europeo de Desarrollo Regional and the Progeria Research Foundation. J.A.G. is the recipient of a U-Mobility Grant from the Marie Curie cofunding of Regional, National and International Programme (Grant 246550). The Instituto Universitario de Oncología is supported by Obra Social Cajastur. The CNIC is supported by the MINECO and the Pro CNIC Foundation, and it is a Severo Ochoa Center of Excellence (MINECO Award SEV-2015-0505).

yearjournalcountryeditionlanguage
2016-10-31
https://hdl.handle.net/10550/70444