0000000000148737

AUTHOR

Luis Jesús Jiménez-borreguero

showing 4 related works from this author

One-pot preparation of surface modified boehmite nanoparticles with rare-earth cyclen complexes.

2007

We report on the one-pot synthetic procedure of cyclen derivatives bearing three acetate groups attached on boehmite nanoparticles, the complexing capabilities of these inorganic–organic hybrid materials with rare earth cations, and the behaviour as contrast agents or fluorescence probes. Delgado Pinar, Estefania, Estefania.Delgado@uv.es ; Frias Martinez, Juan Carlos, Juan.Frias@uv.es ; Albelda Gimeno, Maria Teresa, Teresa.Albelda@uv.es ; Alarcon Navarro, Javier, Javier.Alarcon@uv.es ; Garcia-España Monsonis, Enrique, Enrique.Garcia-Es@uv.es

BoehmiteSurface PropertiesUNESCO::QUÍMICARare earthInorganic chemistryNanoparticleAluminum HydroxideCyclams:QUÍMICA [UNESCO]FluorescenceCatalysischemistry.chemical_compoundSynteticCyclenHeterocyclic CompoundsPolymer chemistryMaterials ChemistryNanoparticles ; Syntetic ; Acetate ; Capabilities ; Inorganic-organic ; FluorescenceAluminum OxideInorganic organicInorganic-organicAcetateSurface modifiedUNESCO::QUÍMICA::Química analíticaMetals and AlloysGeneral ChemistryCapabilitiesFluorescenceSurfaces Coatings and FilmsElectronic Optical and Magnetic Materialschemistry:QUÍMICA::Química analítica [UNESCO]Ceramics and CompositesNanoparticlesMetals Rare EarthHybrid materialChemical communications (Cambridge, England)
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Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations

2016

This work was supported by Spanish Ministry of Economy and Competitiveness (MINECO) Grants SAF2010-16044 and SAF2013-46663-R (to V.A.), SAF2011-30312 and SAF2014-58286-C2-1-R (to L.H.-M.), SAF2011-30088 (to E.D.), and SAF2014-52413-R (to C.L.-O.) and Fondo de Investigación Sanitaria del Instituto de Salud Carlos III Grants RD12/0042/0028 (to V.A.), RD12/0042/0011 (to J.T.), and RD12/0042/0002 (to L.H.-M.), with cofunding from the Fondo Europeo de Desarrollo Regional and the Progeria Research Foundation. J.A.G. is the recipient of a U-Mobility Grant from the Marie Curie cofunding of Regional, National and International Programme (Grant 246550). The Instituto Universitario de Oncología is sup…

0301 basic medicineMaleHutchinson–Gilford progeria syndrome calcium handling connexin43 prelamin A progerinElectrònica en cardiologia030204 cardiovascular system & hematologyPathogenesisCiencias Biomedicas0302 clinical medicineProgeriaCardiac Conduction System DiseasefisiologiapatologíaTecnología médicaChildCiencias médicasMice KnockoutProgeriaprelamin AMultidisciplinaryintegumentary systemMetalloendopeptidasesHeartProgerinHutchinson-Gilford progeria syndrome3. Good health:Enginyeria biomèdica::Electrònica biomèdica::Electrònica en cardiologia [Àrees temàtiques de la UPC]Sarcoplasmic Reticulummedicine.anatomical_structurePNAS PlusChild Preschoolcardiovascular systemNuclear laminaFemalemedicine.symptomBradycardiaAdultmedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesAdolescentBiology03 medical and health sciencesQRS complexYoung AdultElectrònica mèdicaInternal medicinemedicineAnimalsHumansPR intervalHutchinson–Gilford progeria syndromeNuclear LaminaMyocardiumMembrane Proteinsnutritional and metabolic diseasesArrhythmias Cardiacmedicine.diseaseMedical electronicsconnexin43Mice Inbred C57BL030104 developmental biologyEndocrinologyVentricleprogerinConnexin 43calcium handlingsistema cardiovascularCalcium
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Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite

2011

International audience; The synthesis of boehmite nanoparticles modified with lanthanides (Eu, Tb and Gd) is described. Their synthesis, characterization and in vitro assays with HeLa cells were performed. The nuclear magnetic relaxation dispersion (NMRD) profiles of the two chelating moieties were studied. Imaging data from laser scanning confocal fluorescence microscopy and flow cytometry revealed that the nanoscaffolds were taken up by the cells, distributed throughout the cytoplasm and showed no toxicity. This platform could represent an alternative to silica-based inert matrices as imaging vehicles.

LanthanideBoehmiteGADOLINIUM(III) COMPLEXESRELAXIVITYConfocalEUROPIUMchemistry.chemical_elementNanoparticleMetal NanoparticlesAluminum Hydroxide02 engineering and technology010402 general chemistry01 natural sciencesLanthanoid Series ElementsPROBESInorganic ChemistryCoordination ComplexesMicroscopyFluorescence microscopeAluminum OxideNANOPARTICLESHumans[CHIM]Chemical SciencesParticle SizeCYCLEN COMPLEXESFluorescent DyesMicroscopy ConfocalMRI CONTRAST AGENTS021001 nanoscience & nanotechnologyFlow Cytometry0104 chemical scienceschemistryWATER-EXCHANGELUMINESCENCE0210 nano-technologyEuropiumLuminescenceEMISSIONNuclear chemistryHeLa Cells
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Nanoparticles as Contrast Agents for MRI of Atherosclerotic Lesions

2008

Nanoparticle contrast agents for MRI may aid in identifying atherosclerotic lesions that give rise to ischemic events by means of penetration and retention in the plaque. These imaging agents may provide valuable information regarding plaque characteristics which can help determine the risk of plaque rupture. By increasing molecular flexibility or adding a means of specifically targeting ligands via antibody or peptide, nanoparticles can enhance certain regions of the atherosclerotic plaque. The development of single contrast agents detectable with multiple imaging modalities may further improve our ability to detect and characterize atherosclerosis in clinical and preclinical applications.…

lcsh:Diseases of the circulatory (Cardiovascular) systembusiness.industryPlaque ruptureClinical scienceBioinformaticsOriginal researchImaging modalitieslcsh:RC666-701Drug deliverySingle contrastMedicineCancer geneCardiology and Cardiovascular MedicinebusinessTargeting ligandsClinical medicine. Cardiology
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