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RESEARCH PRODUCT
Lanthanide complexes as imaging agents anchored on nano-sized particles of boehmite
Javier AlarcónÉVa TóthM. Teresa AlbeldaEnrique García-españaEstefanía Delgado-pinarOlga BarreiroJuan C. FríasEmilio TejeraVojtěch KubíčekFrancisco Sánchez-madridLuis Jesús Jiménez-borreguerosubject
LanthanideBoehmiteGADOLINIUM(III) COMPLEXESRELAXIVITYConfocalEUROPIUMchemistry.chemical_elementNanoparticleMetal NanoparticlesAluminum Hydroxide02 engineering and technology010402 general chemistry01 natural sciencesLanthanoid Series ElementsPROBESInorganic ChemistryCoordination ComplexesMicroscopyFluorescence microscopeAluminum OxideNANOPARTICLESHumans[CHIM]Chemical SciencesParticle SizeCYCLEN COMPLEXESFluorescent DyesMicroscopy ConfocalMRI CONTRAST AGENTS021001 nanoscience & nanotechnologyFlow Cytometry0104 chemical scienceschemistryWATER-EXCHANGELUMINESCENCE0210 nano-technologyEuropiumLuminescenceEMISSIONNuclear chemistryHeLa Cellsdescription
International audience; The synthesis of boehmite nanoparticles modified with lanthanides (Eu, Tb and Gd) is described. Their synthesis, characterization and in vitro assays with HeLa cells were performed. The nuclear magnetic relaxation dispersion (NMRD) profiles of the two chelating moieties were studied. Imaging data from laser scanning confocal fluorescence microscopy and flow cytometry revealed that the nanoscaffolds were taken up by the cells, distributed throughout the cytoplasm and showed no toxicity. This platform could represent an alternative to silica-based inert matrices as imaging vehicles.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-05-18 |