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RESEARCH PRODUCT
Effects of high-frequency repetitive transcranial magnetic stimulation of primary motor cortex on laser-evoked potentials in migraine.
Paolo LambertiFilippo BrighinaClaudia SerpinoVito De Vito FrancescoVittorio SciruicchioR. SantostasiBrigida FierroMarina De TommasoPaolo LivreaEleonora Vecchiosubject
AdultMaleLaser-Evoked PotentialsOriginalMagnetic Field TherapyMigraine DisordersRepetitive transcranial magnetic stimulationmedicine.medical_treatmentClinical NeurologyPainStimulationbehavioral disciplines and activitiesCohort StudiesYoung AdultElectromagnetic FieldsHumansPain ManagementMedicineTrigeminal NerveEvoked potentialEvoked PotentialsMigraineTrigeminal nerveNeuronal Plasticitybusiness.industryLasersLaser-evoked potentialsGeneral Medicinemedicine.diseaseTranscranial Magnetic StimulationLaser-evoked potentialTranscranial magnetic stimulationAnesthesiology and Pain Medicinemedicine.anatomical_structureMigraineAnesthesiaMotor cortexFemaleMigraine; Laser-evoked potentials; Motor cortex ; Repetitive transcranial magnetic stimulationSettore MED/26 - NeurologiaNeurology (clinical)Primary motor cortexbusinessMotor cortexdescription
The aim of this study was to examine the effects of high-frequency (HF) repetitive transcranial magnetic stimulation (rTMS) of the left primary motor cortex (M1) on subjective pain and evoked responses induced by laser stimulation (LEPs) of the contralateral hand and supraorbital zone in a cohort of migraine patients without aura during the inter-critical phase, and to compare the effects with those of non-migraine healthy controls. Thirteen migraine patients and 12 sex- and age-matched controls were evaluated. Each rTMS session consisted of 1,800 stimuli at a frequency of 5 Hz and 90% motor threshold intensity. Sham (control) rTMS was performed at the same stimulation position. The vertex LEP amplitude was reduced at the trigeminal and hand levels in the sham-placebo condition and after rTMS to a greater extent in the migraine patients than in healthy controls, while the laser pain rating was unaffected. These results suggest that HF rTMS of motor cortex and the sham procedure can both modulate pain-related evoked responses in migraine patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-08-01 |