6533b7d7fe1ef96bd1267841
RESEARCH PRODUCT
Impact of prompt gamma emission of 44Sc on quantification in preclinical and clinical PET systems
Manuela A HoffmannSamer EzziddinAndrea Schaefer-schulerHans-georg BuchholzFadi KhreishEuy Sung MoonFrank RöschMathias SchreckenbergerAchim DenigDaniel Vincenz-zörnerFlorian RosarFlorian RosarHendrik Bohnenbergersubject
RadiationMaterials sciencemedicine.diagnostic_testAstrophysics::High Energy Astrophysical PhenomenaPhysics::Medical PhysicsPositron emittersGamma rayPet imagingPhoton energy010403 inorganic & nuclear chemistry01 natural sciencesQuantitative accuracyCoincidence030218 nuclear medicine & medical imaging0104 chemical sciences03 medical and health sciences0302 clinical medicineNuclear magnetic resonancePositron emission tomographymedicinePhysics::Accelerator PhysicsPet quantificationdescription
Abstract 44Sc is an increasingly investigated positron emitter for use in positron emission tomography (PET) imaging. However, 44Sc is a non-pure positron emitter, since prompt photons are co-emitted during the decay process. This study investigates coincidence energy spectra of 44Sc and its impact on PET quantification on a preclinical and clinical PET system in comparison with 18F. The raw data of the coincidence events revealed characteristic differences comparing the photon energy distribution of 44Sc and 18F. Due to prompt gamma emission of 44Sc, activity recovery is underestimated on PET systems. However, clinical PET imaging of 44Sc with acceptable quantitative accuracy appears feasible by using a single, constant correction factor.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-04-01 | Applied Radiation and Isotopes |