6533b7d7fe1ef96bd126828a
RESEARCH PRODUCT
Bronchiektasen und Infekthäufigkeit bei Alpha-1-Antitrypsin-Mangel
A. HoffmannHans-ulrich KauczorJens SchlegelPeter MildenbergerK. SchunkH. Mehdikhanisubject
Recurrent infectionsmedicine.medical_specialtyBronchial wallAlpha 1-antitrypsin deficiencyBronchiectasisbusiness.industryRadiographyrespiratory systemmedicine.diseaserespiratory tract diseasesMedicineRadiology Nuclear Medicine and imagingIn patientThickeningRadiologybusinessClinical recorddescription
UNLABELLED PURPOSE of this study was to determine the prevalence of bronchiectasis in patients suffering from alpha-1-antitrypsin deficiency and to compare its extent with the frequency of infections. MATERIAL AND METHODS High-resolution CT examinations (HRCT) of 23 patients with alpha-1-antitrypsin deficiency were retrospectively assessed for extent, severity and localisation of bronchiectasis, bronchial wall thickening and extent of emphysema. Chest radiographs and clinical records were available for correlation. RESULTS HRCT scans showed bronchiectasis in 14 of 23 patients, bronchial wall thickening in 3/14, and panlobular emphysema in 23/23. Chest radiographs showed bronchiectasis in 4/23 patients. Only two of 9 patients without bronchiectasis had a history of infections; all 8 patients with multiple bronchiectasis had a history of recurrent infections. CONCLUSION Bronchiectasis is a common finding in alpha-1-antitrypsin deficiency, and is associated with recurrent infections. HRCT is superior to chest radiography as an indicator for the risk of infection in these patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-11-01 | RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren |